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Clinical Pediatrics, Vol. 45, No. 9, 809-818 (2006)
DOI: 10.1177/0009922806294218

Melatonin Treatment in Adolescents With Delayed Sleep Phase Syndrome

Amir Szeinberg, MD

Institute for Fatigue and Sleep Medicine, Sheba Medical Center, Tel Hashomer, Israel

Katy Borodkin, MA

Institute for Fatigue and Sleep Medicine, Sheba Medical Center, Tel Hashomer, Israel

Yaron Dagan, DSc

Institute for Fatigue and Sleep Medicine, Sheba Medical Center, Tel Hashomer, Israel, Department of Behavioral Sciences, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

This retrospective study describes the effects of long-term treatment with melatonin in 33 adolescents (age range, 10-18 years) with delayed sleep phase syndrome (DSPS). Patients were treated with oral melatonin, 3 to 5 mg/day for an average period of 6 months. During the treatment, sleep onset was advanced and sleep duration was longer. Treatment was also associated with a decrease in the proportion of patients reporting school difficulties. No adverse effects of melatonin were noted. This study indicates that long-term treatment with melatonin can be beneficial for adolescents with DSPS in terms of sleep-wake schedule and school performance.


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